![]() When empiric treatment is appropriate, suggested antibiotics include ceftriaxone or cefotaxime for infants one to three months of age and ampicillin with gentamicin or with cefotaxime for neonates. Rapid influenza testing and tests for coronavirus disease 2019 (COVID-19) may be of value when those diseases are circulating. Protocols such as Step-by-Step, Laboratory Score, or the Rochester algorithms may be helpful in identifying low-risk patients. Lumbar puncture is not recommended for children older than three months without localizing signs it may also be considered for those from one to three months of age with abnormal laboratory test results. Chest radiography is rarely recommended for children older than 28 days in the absence of localizing signs. Abnormal white blood cell counts have poor sensitivity for invasive bacterial infections procalcitonin and C-reactive protein levels, when available, are more informative. Urinary tract infections are the most common serious bacterial infection in children younger than three years, so evaluation for such infections should be performed in those with unexplained fever. Factors that suggest serious infection include age younger than one month, poor arousability, petechial rash, delayed capillary refill, increased respiratory effort, and overall physician assessment. Despite dramatic reductions in the rates of bacteremia and meningitis since the 1980s, febrile illness in children younger than 36 months continues to be a concern with potentially serious consequences.
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